Resolving the formidable barrier of oxygen transferring rate (OTR) in ultrahigh-titer bioconversion/biocatalysis by a sealed-oxygen supply biotechnology (SOS).

The vital situation within the competitiveness between bioengineering and chemical engineering is the merchandise titer and the amount productiveness. Essentially the most direct and efficient method normally employs high-density biocatalyst, whereas the weakened mass switch and evoked foam downside accompany ultrahigh-density biocatalyst loading and substrate/product titer.

In high-density obligate cardio bioconversion, oxygen as electron acceptor is a speed-limiting step in bioprocesses, however ample oxygen provide will result in the foaming which ends up in a big discount in oxygen utilization and the usage of further defoamers. On this examine, we designed a novel sealed-oxygen provide (SOS) biotechnology to resolve the formidable barrier of oxygen transferring price (OTR), for bio-based fuels and chemical manufacturing course of.

Outcomes

Based mostly on systemic evaluation of whole-cell catalysis in Gluconobacter oxydans, a novel sealed-oxygen provide expertise was neatly designed and experimentally carried out for biocatalytic oxidation of alcohols, sugars and so forth. By a easy operation ability of computerized on-line provide of oxygen in a sealed stirring tank bioreactor of SOS, OTR barrier and foaming downside was resolved with nice ease.

We lastly obtained ultrahigh-titer merchandise of xylonic acid (XA), 3-hydroxypropionic acid (3-HPA), and erythrulose at 588.four g/L, 69.four g/L, and 364.7 g/L, respectively. Furthermore, the amount productiveness of three chemical merchandise was improved by 150-250% in contrast with regular biotechnology. This SOS expertise offers a promising method to advertise bioengineering competitiveness and benefits over chemical engineering.

SOS expertise was demonstrated as an financial and universally relevant method to bio-based fuels and chemical substances manufacturing by whole-cell catalysis. The novel expertise drastically promotes the competitiveness of bioengineering for chemical engineering, and offers a promising platform for the inexperienced and environmental use of biofuels.

Resolving the formidable barrier of oxygen transferring rate (OTR) in ultrahigh-titer bioconversion/biocatalysis by a sealed-oxygen supply biotechnology (SOS).
Resolving the formidable barrier of oxygen transferring price (OTR) in ultrahigh-titer bioconversion/biocatalysis by a sealed-oxygen provide biotechnology (SOS).

Panel 1: Biotechnology, biomedical engineering and new fashions of otitis media.

To summarize not too long ago revealed key articles on the matters of biomedical engineering, biotechnology and new fashions in relation to otitis media (OM).Digital databases: PubMed, Ovid Medline, Cochrane Library and Scientific Proof (BMJ Publishing).Articles on biomedical engineering, biotechnology, materials science, mechanical and animal fashions in OM revealed between Might 2015 and Might 2019 have been recognized and subjected to overview. A complete of 132 articles have been finally included.

EGFR antibody

10R-E101a 250 ug
EUR 1158
Description: Mouse monoclonal EGFR antibody

EGFR antibody

20R-2384 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-2385 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-2414 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-2688 50 ug
EUR 337.2
Description: Goat polyclonal EGFR antibody

EGFR antibody

20R-2968 100 ul
EUR 471.6
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-ER004 250 µL
EUR 804
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-ER022 50 ug
EUR 787.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-ER023 50 ug
EUR 787.2
Description: Rabbit polyclonal EGFR antibody

EGFR Antibody

23630-100ul 100ul
EUR 468

EGFR antibody

20R-1723 100 ug
EUR 807.6
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-1940 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-1941 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-2032 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-2033 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-2062 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-2068 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-2069 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-2096 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-2177 50 ug
EUR 337.2
Description: Goat polyclonal EGFR antibody

EGFR antibody

20R-2254 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-2255 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-2356 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-2357 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20R-2376 50 ug
EUR 337.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

20-ES04 250 ug
EUR 586.8
Description: Sheep polyclonal EGFR antibody

EGFR Antibody

3782-100 each
EUR 405.6

EGFR antibody

38493-100ul 100ul
EUR 302.4

EGFR antibody

70R-30569 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

70R-30571 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody

EGFR Antibody

BF9105 200ul
EUR 540

EGFR Antibody

AF0436 200ul
EUR 420

EGFR Antibody

AF6041 200ul
EUR 420

EGFR Antibody

AF6042 200ul
EUR 420

EGFR Antibody

AF6043 200ul
EUR 420

EGFR Antibody

AF6045 200ul
EUR 420

EGFR Antibody

AF6046 200ul
EUR 420

EGFR Antibody

AF6047 200ul
EUR 420

EGFR Antibody

AF6049 200ul
EUR 420

EGFR Antibody

AF6052 200ul
EUR 420

EGFR antibody

70R-11425 50 ug
EUR 236.4
Description: Rabbit polyclonal EGFR antibody for specific detection of the non-phosphorylated Ser1070 form of the EGFR peptide.

EGFR antibody

70R-12084 100 ul
EUR 523.2
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

70R-17018 50 ul
EUR 522
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

70R-31553 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

70R-33569 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

70R-37513 100 ug
EUR 327.6
Description: Rabbit Polyclonal EGFR antibody

EGFR antibody

70R-37514 100 ug
EUR 327.6
Description: Rabbit Polyclonal EGFR antibody

EGFR antibody

70R-51525 100 ul
EUR 344.4
Description: Purified Polyclonal EGFR antibody

EGFR antibody

70R-51526 100 ul
EUR 292.8
Description: Purified Polyclonal EGFR antibody

EGFR antibody

70R-49690 100 ul
EUR 344.4
Description: Purified Polyclonal EGFR antibody

EGFR antibody

70R-49691 100 ul
EUR 292.8
Description: Purified Polyclonal EGFR antibody

EGFR antibody

70R-34091 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

70R-34093 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

70R-34095 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

70R-34097 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

70R-34099 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

70R-34101 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody

EGFR antibody

70R-35670 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody

EGFR Antibody

36836-100ul 100ul
EUR 302.4

EGFR Antibody

48691-100ul 100ul
EUR 399.6

EGFR Antibody

48691-50ul 50ul
EUR 286.8

EGFR Antibody

48714-100ul 100ul
EUR 399.6

EGFR Antibody

48714-50ul 50ul
EUR 286.8

EGFR Antibody

ABF0436 100 ug
EUR 525.6

EGFR Antibody

ABF6042 100 ug
EUR 525.6

EGFR Antibody

ABF6043 100 ug
EUR 525.6

EGFR Antibody

ABF6052 100 ug
EUR 525.6

EGFR Antibody

ABD7105 100 ug
EUR 525.6

EGFR Antibody

1-CSB-PA005571LA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EGFR. Recognizes EGFR from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200

EGFR Antibody

1-CSB-PA162597
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against EGFR. Recognizes EGFR from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:15-1:50

EGFR Antibody

1-CSB-PA10279A0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EGFR. Recognizes EGFR from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:500-1:1000

EGFR Antibody

1-CSB-PA007479GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against EGFR. Recognizes EGFR from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB

EGFR Antibody

1-CSB-PA007971
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EGFR. Recognizes EGFR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

EGFR Antibody

1-CSB-PA007973
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EGFR. Recognizes EGFR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/40000

EGFR Antibody

1-CSB-PA007976
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EGFR. Recognizes EGFR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000

EGFR Antibody

1-CSB-PA007977
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EGFR. Recognizes EGFR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

EGFR Antibody

1-CSB-PA007978
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EGFR. Recognizes EGFR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000

EGFR Antibody

1-CSB-PA002264
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EGFR. Recognizes EGFR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000

EGFR Antibody

1-CSB-PA002267
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EGFR. Recognizes EGFR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

EGFR Antibody

1-CSB-PA002273
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EGFR. Recognizes EGFR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/40000

EGFR Antibody

1-CSB-PA002275
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EGFR. Recognizes EGFR from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

EGFR Antibody

1-CSB-PA002281
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against EGFR. Recognizes EGFR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/5000

Egfr Antibody

F52880-0.08ML 0.08 ml
EUR 140.25
Description: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.

Egfr Antibody

F52880-0.4ML 0.4 ml
EUR 322.15
Description: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.

EGFR Antibody

F40415-0.4ML 0.4 ml
EUR 330.65
Description: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

EGFR Antibody

F47591-0.08ML 0.08 ml
EUR 140.25
Description: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

EGFR Antibody

F49183-0.4ML 0.4 ml
EUR 322.15
Description: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.

EGFR Antibody

R35328-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Epidermal growth factor receptor

EGFR Antibody

R31449 100 ug
EUR 356.15
Description: The epidermal growth factor receptor (EGFR; ErbB1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB1), HER2/c-neu (ErbB2), Her 3 (ErbB3) and Her 4 (ErbB4). It exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGFalpha). EGFR and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development. Mutations that lead to overexpression or overactivity have been associated with a number of cancers, including lung cancer and glioblastoma multiform.

EGFR Antibody

RQ4838 100ul
EUR 356.15
Description: EGFR is a receptor tyrosine kinase. Receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation.

anti- EGFR antibody

FNab10146 100µg
EUR 702
Description: Antibody raised against EGFR

anti- EGFR antibody

FNab02667 100µg
EUR 702
Description: Antibody raised against EGFR

anti- EGFR antibody

FNab02668 100µg
EUR 702
Description: Antibody raised against EGFR

EGFR antibody (Thr678)

70R-30568 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody (Thr678)

EGFR antibody (Thr693)

70R-30570 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody (Thr693)

EGFR antibody (Ser695)

70R-32596 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody (Ser695)

EGFR antibody (Thr678)

70R-37260 100 ug
EUR 418.8
Description: Rabbit Polyclonal EGFR antibody (Thr678)

EGFR antibody (Thr693)

70R-37261 100 ug
EUR 418.8
Description: Rabbit Polyclonal EGFR antibody (Thr693)

EGFR antibody (Tyr869)

70R-37295 100 ug
EUR 418.8
Description: Rabbit Polyclonal EGFR antibody (Tyr869)

EGFR antibody (Tyr869)

70R-34100 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody (Tyr869)

phospho EGFR antibody

10R-E125a 100 ul
EUR 898.8
Description: Mouse monoclonal phospho EGFR antibody

EGFR antibody (Ser1026)

70R-32597 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody (Ser1026)

EGFR antibody (Ser1071)

70R-32598 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody (Ser1071)

EGFR antibody (Tyr1069)

70R-33568 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody (Tyr1069)

EGFR antibody (Tyr1016)

70R-36530 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody (Tyr1016)

EGFR antibody (Ser1070)

70R-37161 100 ug
EUR 418.8
Description: Rabbit Polyclonal EGFR antibody (Ser1070)

EGFR antibody (Tyr1092)

70R-37162 100 ug
EUR 418.8
Description: Rabbit Polyclonal EGFR antibody (Tyr1092)

EGFR antibody (Tyr1172)

70R-37287 100 ug
EUR 418.8
Description: Rabbit Polyclonal EGFR antibody (Tyr1172)

EGFR antibody (Tyr1197)

70R-37294 100 ug
EUR 418.8
Description: Rabbit Polyclonal EGFR antibody (Tyr1197)

EGFR antibody (Tyr1110)

70R-37323 100 ug
EUR 418.8
Description: Rabbit Polyclonal EGFR antibody (Tyr1110)

EGFR antibody (Ser1070)

70R-34090 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody (Ser1070)

EGFR antibody (Tyr1092)

70R-34092 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody (Tyr1092)

EGFR antibody (Tyr1110)

70R-34094 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody (Tyr1110)

EGFR antibody (Tyr1172)

70R-34096 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody (Tyr1172)

EGFR antibody (Tyr1197)

70R-34098 100 ug
EUR 392.4
Description: Rabbit polyclonal EGFR antibody (Tyr1197)

Polyclonal EGFR Antibody

APR00195G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EGFR . This antibody is tested and proven to work in the following applications:

Polyclonal EGFR Antibody

APR05964G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EGFR . This antibody is tested and proven to work in the following applications:

Polyclonal EGFR Antibody

APR02136G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EGFR . This antibody is tested and proven to work in the following applications:

EGF Receptor / EGFR Antibody

RQ5720 100 ug
EUR 356.15
Description: The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). EGFR exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGFalpha). EGFR and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer and glioblastoma multiforme. In this latter case a more or less specific mutation of EGFR, called EGFRvIII is often observed.

EGF Receptor / EGFR Antibody

RQ5881 100 ug
EUR 356.15
Description: The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). EGFR exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor ? (TGF?). EGFR and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer and glioblastoma multiforme. In this latter case a more or less specific mutation of EGFR, called EGFRvIII is often observed.

Egf Receptor / Egfr Antibody

RQ6913 100ug
EUR 356.15
Description: The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands. It is mapped to 11 A2; 11 9.41 cM. The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.

EGF Receptor / EGFR Antibody

V3327-100UG 100 ug
EUR 349.3
Description: Epidermal growth factor receptor (EGFR) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor a. Upon activation by its growth factor ligands, EGFR undergoes a transition from an inactive monomeric form to an active homodimer. In addition to forming homodimers after ligand binding, EGFR may pair with another member of the ErbB receptor family, such as ErbB2/Her2/neu, to create an activated heterodimer. EGFR dimerization stimulates its intrinsic intracellular protein-tyrosine kinase activity. As a result, autophosphorylation of several tyrosine (Y) residues in the C-terminal domain of EGFR occurs. This autophosphorylation elicits downstream activation and signaling by several other proteins that associate with the phosphorylated tyrosines through their own phosphotyrosine-binding SH2 domains. These downstream signaling proteins initiate several signal transduction cascades, principally the MAPK, Akt and JNK pathways, leading to DNA synthesis and cell proliferation. [Wiki]

EGF Receptor / EGFR Antibody

V3327-20UG 20 ug
EUR 153.3
Description: Epidermal growth factor receptor (EGFR) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor a. Upon activation by its growth factor ligands, EGFR undergoes a transition from an inactive monomeric form to an active homodimer. In addition to forming homodimers after ligand binding, EGFR may pair with another member of the ErbB receptor family, such as ErbB2/Her2/neu, to create an activated heterodimer. EGFR dimerization stimulates its intrinsic intracellular protein-tyrosine kinase activity. As a result, autophosphorylation of several tyrosine (Y) residues in the C-terminal domain of EGFR occurs. This autophosphorylation elicits downstream activation and signaling by several other proteins that associate with the phosphorylated tyrosines through their own phosphotyrosine-binding SH2 domains. These downstream signaling proteins initiate several signal transduction cascades, principally the MAPK, Akt and JNK pathways, leading to DNA synthesis and cell proliferation. [Wiki]

New imaging applied sciences for the tympanic membrane (TM) and the center ear cavity are being developed to evaluate TM thickness, establish biofilms and differentiate kinds of center ear effusions. Synthetic intelligence (AI) has been utilized to coach software program applications to diagnose OM with a excessive diploma of certainty. Genetically modified mice fashions for OM have additional investigated what predisposes some people to OM and consequent listening to loss. New vaccine candidates defending in opposition to main otopathogens are being explored and developed, particularly mixed vaccines, concentrating on multiple pathogen.

Transcutaneous vaccination in opposition to non-typeable Haemophilus influenzae has been efficiently tried in a chinchilla mannequin. When it comes to remedy, novel applied sciences for trans-tympanic drug supply are getting into the scientific area. Varied development components and grafting supplies geared toward enhancing therapeutic of TM perforations present promising leads to animal fashions.

New applied sciences and AI purposes to enhance the analysis of OM have proven promise in pre-clinical fashions and are steadily getting into the scientific area. So are novel vaccines and drug supply approaches that will permit native remedy of OM.New diagnostic strategies, potential vaccine candidates and the novel trans-tympanic drug supply present promising outcomes, however are usually not but tailored to scientific use.

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